1,1,1,2-TETRAFLUOROETHANE | CAMEO Chemicals | NOAA (2024)


Chemical Datasheet

1,1,1,2-TETRAFLUOROETHANE | CAMEO Chemicals | NOAA (1)

ChemicalIdentifiers | Hazards | ResponseRecommendations |PhysicalProperties |RegulatoryInformation | AlternateChemicalNames

Chemical Identifiers

What is this information?

The Chemical Identifier fields include common identification numbers, theNFPA diamond U.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of data sources.

CAS Number UN/NA Number DOT Hazard Label USCG CHRIS Code
  • 811-97-2 1,1,1,2-TETRAFLUOROETHANE | CAMEO Chemicals | NOAA (2)
  • 3159
  • Non-Flammable Gas
NIOSH Pocket Guide International Chem Safety Card

NFPA 704

data unavailable

General Description

A colorless gas with a slight ethereal odor. Vapors are heavier than air. Shipped liquefied under own vapor pressure. Flash point 351°F. Inhalation at high concentrations is harmful and may cause heart irregularities, unconsciousness or death without warning. Liquid contact may cause frostbite. Vapors can replace the available oxygen.


What is this information?

The Hazard fields include special hazard alerts air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. The information in CAMEO Chemicals comes from a variety of data sources.

Reactivity Alerts


Air & Water Reactions

Insoluble in water.

Fire Hazard

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Some may burn but none ignite readily. Containers may explode when heated. Ruptured cylinders may rocket. CAUTION: Aerosols (UN1950) may contain a flammable propellant. (ERG, 2020)

Health Hazard

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating, corrosive and/or toxic gases. (ERG, 2020)

Reactivity Profile

1,1,1,2-TETRAFLUOROETHANE is chemically inert in many situations, but can react violently with strong reducing agents such as the very active metals and the active metals. Can react with strong oxidizing agents or weaker oxidizing agents under extremes of temperature.

Belongs to the Following Reactive Group(s)

  • Fluorinated Organic Compounds

Potentially Incompatible Absorbents

No information available.

Response Recommendations

What is this information?

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.

Isolation and Evacuation

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 500 meters (1/3 mile).

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)


Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Use extinguishing agent suitable for type of surrounding fire.

SMALL FIRE: Dry chemical or CO2.

LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Damaged cylinders should be handled only by specialists.

FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. Some of these materials, if spilled, may evaporate leaving a flammable residue. (ERG, 2020)

Non-Fire Response

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Do not touch or walk through spilled material. Stop leak if you can do it without risk. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basem*nts or confined areas. Allow substance to evaporate. Ventilate the area. (ERG, 2020)

Protective Clothing

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2020)

DuPont Tychem® Suit Fabrics

Fabric legend, testing details, and a caution from DuPont

Tychem® Fabric Legend

QS = Tychem 2000 SFR
QC = Tychem 2000
SL = Tychem 4000
C3 = Tychem 5000
TF = Tychem 6000
TP = Tychem 6000 FR
TK = Tychem 10000
RF = Tychem 10000 FR

Testing Details

The fabric permeation data was generated for DuPont by a third party laboratory. Permeation data for industrial chemicals is obtained per ASTM F739. Normalized breakthrough times (the time at which the permeation rate exceeds 0.1 μg/cm2/min) are reported in minutes. All chemicals have been tested between approximately 20°C and 27°C unless otherwise stated. All chemicals have been tested at a concentration of greater than 95% unless otherwise stated.

Chemical warfare agents (Lewisite, Sarin, Soman, Sulfur Mustard, Tabun and VX Nerve Agent) have been tested at 22°C and 50% relative humidity per military standard MIL-STD-282. "Breakthrough time" for chemical warfare agents is defined as the time when the cumulative mass which permeated through the fabric exceeds the limit in MIL-STD-282 [either 1.25 or 4.0 μg/cm2].

A Caution from DuPont

This information is based upon technical data that DuPont believes to be reliable on the date issued. It is subject to revision as additional knowledge and experience are gained. The information reflects laboratory performance of fabrics, not complete garments, under controlled conditions. It is intended for informational use by persons having technical skill for evaluation under their specific end-use conditions, at their own discretion and risk. It is the user's responsibility to determine the level of toxicity and the proper personal protective equipment needed. Anyone intending to use this information should first verify that the garment selected is suitable for the intended use. In many cases, seams and closures have shorter breakthrough times and higher permeation rates than the fabric. If fabric becomes torn,abraded or punctured, or if seams or closures fail, or if attached gloves, visors, etc. are damaged, end user should discontinue use of garment to avoid potential exposure to chemical. Since conditions of use are outside our control, DuPont makes no warranties, express or implied, including, without limitation, no warranties of merchantability or fitness for a particular use and assume no liability in connection with any use of this information. This information is not intended as a license to operate under or a recommendation to infringe any patent, trademark or technical information of DuPont or others covering any material or its use.

Normalized Breakthrough Times (in Minutes)
Chemical CAS Number State QS QC SL C3 TF TP RC TK RF
Norflurane 811-97-2 Vapor >480 >480 >480 >480 >480 >480
Tetrafluoroethane, 1,1,1,2- 811-97-2 Vapor >480 >480 >480 >480 >480 >480

> indicates greater than.

Special Warning from DuPont: Tychem® and Tyvek® fabrics should not be used around heat, flames, sparks or in potentially flammable or explosive environments. Only...

More Info...

...Tychem® ThermoPro, Tychem® Reflector® and Tychem® TK styles 600T/601T (with aluminized outer suit) garments are designed and tested to help reduce burn injury during escape from a flash fire. Users of Tychem® ThermoPro, Tychem® Reflector® and Tychem® TK styles 600T/601T (with aluminized outer suit) garments should not knowingly enter an explosive environment. Tychem® garments with attached socks must be worn inside protective outer footwear and are not suitable as outer footwear. These attached socks do not have adequate durability or slip resistance to be worn as the outer foot covering.

(DuPont, 2023)

First Aid

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Call 911 or emergency medical service. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air if it can be done safely. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with liquefied gas, thaw frosted parts with lukewarm water. Keep victim calm and warm. (ERG, 2020)

Physical Properties

What is this information?

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds The information in CAMEO Chemicals comes from a variety of data sources.

Note: For Vapor Density and Specific Gravity, comparing the value to 1.0 can tell you if the chemical will likely sink/rise in air or sink/float in fresh water (respectively). Short phrases have been added to those values below as an aid. However, make sure to also consider the circ*mstances of a release. The Vapor Density comparisons are only valid when the gas escaping is at the same temperature as the surrounding air itself. If the chemical is escaping from a container where it was pressurized or refrigerated, it may first escape and behave as a heavy gas and sink in the air (even if it has a Vapor Density value less than 1). Also, the Specific Gravity comparisons are for fresh water (density 1.0 g/mL). If your spill is in salt water (density about 1.027 g/mL), you need to adjust the point of comparison. There are some chemicals that will sink in fresh water and float in salt water.

Chemical Formula:
  • C2H2F4

Flash Point: data unavailable

Lower Explosive Limit (LEL): data unavailable

Upper Explosive Limit (UEL): data unavailable

Autoignition Temperature: data unavailable

Melting Point: data unavailable

Vapor Pressure: data unavailable

Vapor Density (Relative to Air): data unavailable

Specific Gravity: data unavailable

Boiling Point: data unavailable

Molecular Weight: 102.0303

Water Solubility: data unavailable

Ionization Energy/Potential: data unavailable

IDLH: data unavailable

AEGLs (Acute Exposure Guideline Levels)

Final AEGLs for HFC 134A (811-97-2)
Exposure Period AEGL-1 AEGL-2 AEGL-3
10 minutes 8000 ppm 13000 ppm 27000 ppm
30 minutes 8000 ppm 13000 ppm 27000 ppm
60 minutes 8000 ppm 13000 ppm 27000 ppm
4 hours 8000 ppm 13000 ppm 27000 ppm
8 hours 8000 ppm 13000 ppm 27000 ppm

(NAC/NRC, 2023)

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

Chemical PAC-1 PAC-2 PAC-3
HFC 134a; (Tetrafluoroethane, 1,1,1,2-) (811-97-2) 8000 ppm 13000 ppm 27000 ppm

(DOE, 2018)

Regulatory Information

What is this information?

The Regulatory Information fields include information from the U.S. Environmental Protection Agency's Title III Consolidated List of Lists, the U.S. Cybersecurity and Infrastructure Security Agency's Chemical Facility Anti-Terrorism Standards, and the U.S. Occupational Safety and Health Administration's Process Safety Management of Highly Hazardous Chemicals Standard List (see more about these data sources).

EPA Consolidated List of Lists

No regulatory information available.

CISA Chemical Facility Anti-Terrorism Standards (CFATS)

No regulatory information available.

OSHA Process Safety Management (PSM) Standard List

No regulatory information available.

Alternate Chemical Names

What is this information?

This section provides a listing of alternate names for this chemical, including trade names and synonyms.

  • DAIFLON 134A

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1,1,1,2-TETRAFLUOROETHANE | CAMEO Chemicals | NOAA (2024)


Is 1,1,1,2-tetrafluoroethane toxic? ›

HFC-134a is a colorless gas with a faint ethereal odor that may go unnoticed by most individuals. HFC-134a has a very low acute inhalation toxicity.

What is the common name for 1,1,1,2-tetrafluoroethane? ›

For its medical uses, 1,1,1,2-tetrafluoroethane has the generic name norflurane. It is used as propellant for some metered dose inhalers.

Is Tetrafluoroethane hazardous? ›

Inhalation at high concentrations is harmful and may cause heart irregularities, unconsciousness or death without warning. Liquid contact may cause frostbite. Vapors can replace the available oxygen.

What chemical compound does r134a contain? ›

R-134a (Halocarbon 134a, C2H2F4, 1,1,1,2-tetrafluoroethane)

Why is R134a banned? ›

Why are restrictions being imposed? The short answer is that the Global Warming Potential (GWP) of HFC-134a is significant and there are replacement gases available that have less environmental impact.

What is the most toxic refrigerant? ›

The most common toxic refrigerant is ammonia, and you would generally only find it in old appliances or large industrial applications. Propane (R290) is a flammable refrigerant and is becoming quite popular in small self-contained refrigeration units like vending machines and reach-in coolers.

What happens when you inhale tetrafluoroethane? ›

R-134a (1,1,1,2-tetrafluoroethane) is widely used as a refrigerant and as an aerosol propellant. Inhalation of R-134a can lead to asphyxia, transient confusion, and cardiac arrhythmias.

What are the side effects of Tetrafluoroethane? ›

Serious side effects

Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

What is Tetrafluoroethane used for? ›

Use and applications

1,1,1,2-Tetrafluoroethane is an HFC gas broadly used in refrigeration industry (domestic refrigeration, commercial refrigeration, food processing & cold storage, transport & industrial refrigeration) and air conditioning (automotive, building and large systems).

Is R134a refrigerant illegal? ›

R134a is being phased out globally due to its high global warming potential. It's been banned for new vehicle AC systems in the United States, and lower-GWP alternatives are taking its place across industries.

What is R134a being replaced with? ›

Through the Years. In the 1930's through the early '90's FREON, also known as R12, was used in all vehicle air conditioning systems. By the mid 90's R12 was phased out and replaced by 134a refrigerant. Now, nearly 30 years after its introduction, 134a is being replaced by 1234YF Opteon™.

What happens if you get R134a on your skin? ›

Skin contact: Low exposure to liquid will cause redness and pain. High exposure to liquid will cause frostbite, blisters and severe pain. Eye contact: Exposure to liquid will cause severe pain and cornea damage.

Is R134a harmful if inhaled? ›

It can act as a simple asphyxiant by diluting the concentration of oxygen in air to below the levels necessary to support life. Adverse Health effects. The inhalation of high concentrations of R134a vapour may cause temporary central nervous system depression, with narcosis, lethargy and anaesthetic effects.

Is HFC harmful to humans? ›

HFCs can also pose a risk to humans as the HFC gases often are explosive gases that are highly flammable. Exposure to high concentrations of HFCs may cause suffocation as HFCs displace the oxygen from the air7,8. Exposure to high levels of some HFCs may also severely affect the heart9,10.

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